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November 2007 Vol 11 UNDILUTEDEmpire State medical Association Denounces Incomplete research claims made by Dr. Gilbert and Dr. Worobey on HIV coming from Haiti (www.nyesma.org)The
Empire State Medical Association is highly concerned about the
claims by Michael Worobey that
AIDS virus invaded the United States in about
1969 from Haiti, carried most
likely by a single infected immigrant who set
the stage for it to sweep the world in a tragic epidemic. We reject the comments that researchers think an unknown
single infected Haitian
immigrant arrived in a large city like Miami or New
York, and
the virus circulated for years -- first in the U.S. population and
then to other nations. Gilbert
and Worobey, analyzed samples from only five of these Haitian immigrants
dating from 1982 and 1983. They also looked at genetic data from 117 more early AIDS patients from around the world. This
genetic analysis allowed them
to calibrate the molecular clock of the strain of HIV that has
spread most widely, and calculated when it arrived first in Haiti from Africa and then
in the United States. The researchers virtually ruled out the possibility
that HIV had come
directly to the United States from Africa, setting a 99.8
percent probability that Haiti was the
steppingstone. For
Haiti, the history
of HIV/AIDS represents stigma, discrimination,
and racism. In 1982,
scientists at the Centers for Disease Control (CDC) incorrectly inferred
that Haitians were at increased for acquiring HIV
as a racial group (1). HIV/AIDS
therefore became known as the 4H Disease,
affecting homosexuals, heroin addicts, hemophiliacs, and Haitians.
This resulted in unprecedented national stigmatization and
devastating economic, social,
and psychological consequences, decimating the tourist industry
in this island nation. As
reported at the time: Haiti has been made
an international pariah by AIDS.
Boycotted by tourists and investors, it
has lost millions of dollars and thousands of jobs at a time when
half the work force is
jobless. Even exports are
being shunned by some. In
1985, when it became clear
that Haitians share the same risk factors as other groups,
the CDC dropped the Haitian association, but it was too late.
HIV and Haiti
were inextricably linked in the minds of the general public.
Haits
economy has never recovered. Gilbert
et al once again link HIV and Haiti, stating:
Subtype B likely moved from
Africa to Haiti in or around
1966 and then on to the U.S. Their
entire hypothesis is based on virus isolated from five Haitian-Americans
who were living in Miami in 1982-83.
No other information is provided except
that they entered the U.S. after 1975 and progressed to AIDS by 1981 and hence were
presumably infected with HIV-1 before entering the U.S.
A
host of questions remain.
What were their risk activities? Where had they traveled?
Did they have sex with Americans in Haiti? We do know that
the average time of progression of HIV infection to AIDS and to death
in the pre-ART era was 4.5
and 7.4 years, respectively these
intervals are consistent with the
five subjects acquiring the infection in the U.S, which limits the
validity of their findings
(3). The authors go on to
state: The HIV-1 epidemic in Haiti exhibits a
greater range of viral genetic diversity that the rest of the world subtype B combined.
The authors have not studied the
virus in Haiti.
Where are the data to support this claim?
They also state that their aim is to combine phylogenetic,
molecular evolutionary, historical, and epidemiological perspectives in an attempt to reconstruct the history of the subtype B pandemic.
However, epidemiology studies
conducted in Haiti do not support the author’s hypothesis.
If the virus was in circulation in Haiti since 1966,
there would not have been a
much higher male: female ratio in the early years of the epidemic (80% of
the first Haitian patients were male in the early 1980) which
rapidly generalized as they
spread the virus to their female partners (4,5).
In addition, reviews of large samples of banked blood from the 1970 failed
to yield a single case of HIV and thousands
of autopsies did not diagnose an AIDS defining
illness until 1978 (6). Furthermore,
only one case of Kaposs sarcoma (KS)
was noted by Haitian dermatologists prior to 1979 (7).
KS is easily recognizable
and it would not have been missed by Haitian dermatologists for over a decade. Haiti has overcome enormous obstacles and mounted one of the world
most successful responses to the HIV/AIDS epidemic.
Yet, the authors restate prejudices advanced two decades ago in the
publication of Pitchenik et al
(8): Haitians in Haiti and elsewhere
are at risk of AIDS. People of
all ethnicities in every country are at risk.
Scientists need to be very responsible in their assertions, lest
they do great harm. The
American public must also be informed that European scientists
infected many Africans with contaminated polio vaccine that was
cultured with Chimpanzee
kidneys. This is a fact.
This theory as an etiology of AIDS was
outlined in 1999 in the book,
The River: A Journey Back to the Source of HIV and AIDS and the
Canadian documentary entitled the Origin of AIDS. Hooper
mapped the locations where Koprowski's CHAT vaccine was given and
where the earliest cases of AIDS were
discovered. It showed a dramatic geographical correlation.
Text from an interview with Mr. Hooper on the book and movie are as
follows: Edward Hooper:
"The earliest cases of AIDS occurred in central Africa,
in the same regions where Koprowski's vaccine was given to over a
million people in 1957-1960.
I think that what we have here is the route whereby this
chimpanzee virus arrived in humans."
Hooper
claims that kidneys from chimpanzees infected with SIV were used
to grow the polio virus during Dr. Koprowski's 1950's vaccination
campaign. Archival footage
confirms that a large number of chimpanzees were housed at Camp
Lindi, located upstream from Koprowski's medical laboratory in Stanleyville in
the former Belgian Congo. But
in his book Hooper provided evidence to show what happened to the
four hundred chimps brought to the camp and killed in the space of
two years.
Camp assistant Christophe Bayelo, cared for the chimps at Lindi. He
told Hooper that the staff, including Paul Osterrieth, the lab's
head of virology, systemically harvested organs from the camp's chimps.
Joseph
Limbaya, a nurse at the camp remembers that he was ordered to
kill two or three chimps a day. Joseph Limbaya: "We didn't
remove the flesh, but the two
organs located at the back, the two balls called the kidneys."
The
camp workers claimed that some of the animals were dissected alive.
Hooper argued that the main reason for doing so would have been to
harvest living tissue
cultures needed to make the polio vaccine. Paul Osterrieth and Hilary Koprowski steadfastly denied that
chimpanzee tissue was used to
grow the polio virus in the Congo. Before
his death Pierre Doupagne, the chief technician at the laboratory of Stanleyville admitted to Edward Hooper that he
made sterile tissue culture
from chimps for Paul Osterrieth. Edward
Hooper: "The person with overall responsibility for this entire
sequence of events is Dr. Koprowski. Without his approval, this
sequence of events would not
have taken place." Bill
Hamilton, a renowned evolutionary biologist, felt that Hooper's
theory had merit. In an interview with CNN he explained why he felt
it was necessary to take a
closer look. Bill Hamilton:
"I feel it's not only the origin of AIDS that is in
question here, it is the conduct of science towards the hypothesis,
which has been one of
paranoid rejection. I think I would not exaggerate to describe it as
medical science's worst hated hypothesis."
Hamilton
traveled to Africa to collect chimpanzee samples but contracted malaria and died in March 2000. Before his death
he asked the Royal Society of
Scientists in London to stage a debate on the 'hunter vs. the vaccine'
theory of the origin of AIDS.
In September 2000 the world's top AIDS specialists
assembled at London's Royal
Society for a conference on the origins of AIDS. It was meant
to give Edward Hooper a
chance to present his evidence to the scientific community.
From the opening of the conference arguments were launched against
Hooper's theory. Then there was a surprise announcement. Samples of
Kopowski's CHAT vaccine had
been located and tested and found not to have any trace of
HIV, SIV or chimp
DNA. This
announcement was viewed by the scientific community as a decisive
statement against Hooper's theory. Articles were published in Nature
and Science concluded that Hooper's hypothesis was not viable.
Dr. Cecil Fox: "They (the scientists), once again, claimed to
have laid to rest the idea
that HIV could have
come from Polio vaccine and I don't think
they did a better job than they had done before. There are still
great gaping holes in their
story." However Hooper
pointed out that the samples were discovered in the U.S.
and not used in the Congo and that no vaccines still exist from
that time. In
2003 Michael Worobey returned to the Congo to complete the studies
attempted by Bill Hamilton years ago. In a scientific paper
published in April 2004 they
concluded that the SIV found in the chimpanzees near Stanleyville was
not the strain that crossed over to humans to cause HIV years ago. The authors stated
that this provided proof evidence against the polio vaccine theory.
In response, Edward Hooper claims that the chimps used at Camp
Lindi came from a large
geographical area then tested by Worobey. And he maintians,
this means that the researchers cannot claim to have put the issue
to rest. He plans to publish
a book this year in support his theory.
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